Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression.

CIITA activates the expression of multiple genes involved in antigen presentation and it is believed to be required for both constitutive and IFN gamma-inducible expression of these genes. To understand the role of CIITA in vivo, we have used gene targeting to generate mice that lack CIITA. CIITA-deficient (-/-) mice do not express conventional MHC class II molecules on the surface of splenic B...

Deregulated MHC Class II Transactivator

Class II Transactivator Modulation of Gene Expression by the MHC

Transcription by Lytic Transactivator Zta Expression through Inhibition of CIITA Down-Regulation of MHC Class II

PML promotes MHC class II gene expression by stabilizing the class II transactivator

Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major histocompatibility (MHC) locus. In this paper, we have explored potential links between PML and interferon (IFN)-γ-induced MHC class II expression. IFN-γ induced a substantial increase in the spatial proximity between PML bodies and the MHC class II gene...